Antibacterial activity of DL 473, a C3-substituted rifamycin derivative.
نویسنده
چکیده
DL 473 is a 3-[(4-cyclopentyl-1-piperazinyl)iminomethyl] rifamycin SV derivative which inhibited staphylococci, streptococci (including Streptococcus faecalis, Listeria species, and Bacteroides species. DL 473 was less active than rifampin against these species. DL 473 did not inhibit Enterobacteriaceae nor most Pseudomonas species. A combination of DL 473 and vancomycin or nafcillin tested against staphylococci was primarily additive and antagonism was not encountered.
منابع مشابه
Comparison of concentrations of rifampin and a new rifamycin derivative, DL 473, in canine bone.
Constant-infusion experiments were performed in 14 dogs to determine the penetration into bone of rifampin and a new C-3 substituted rifamycin, DL 473. The drugs were assayed in cortical bone and medulla from tibia-femur and cortical and cancellous bone from rib. After identical dosage, the concentrations of DL 473 appeared to be higher, except in the medulla, although the serum concentrations ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1983